Guide to the care and use of experimental animals ccac. Laboratory rats introduction origin and development. Europe asia and pacific austria baltic states belgium canada croatia denmark finland france germany hungary iceland india ireland israel italy japan luxembourg netherlands norway poland portugal singapore south korea. What is the difference between wistar albino rats, sprague. The remaining animals were unavailable due to autolysis. Evaluation of immunomodulatory activity of hydroalcoholic. The development of todays laboratory rat has been essentially an american initiative and the great majority of the strains of. Original contribution open access mitigative effects of. Derived from animals from the wistar institute, philadelphia, pennsylvania. Most are derived from the albino wistar rat, which is still widely used. Recently it was shown that results vary between studies using wistar rats of different suppliers. Common outbred rats include wistar, longevans, and spraguedawley. Wistar defines several vm image types that encapsulates many of the configurable attributes to simplify configuration.
Antiulcer activity of ipomoea batatas tubers sweet potato. Pritchett and others published biology and medicine of the rat find, read and cite all. Toxicology, metabolism, and mutagenicity studies for tbbpa were also discussed, as well as. Common outbred rats include wistar, long evans, and spraguedawley. In this 28 daystudy, we evaluated the effects of herbicide glyphosate administered by gavage to wistar rats at daily doses equivalent to 0. Rats and mice appeared to use different strategies for locating the hidden escape platform. The effects of aframomum melegueta aqueous extract on the. Lead concentration in blood was determined by atomic absorption. Wistar rats from different suppliers have a different.
Tumors occurring in 450 male and 450 female control rats of the strain wistar bor. Baseline hematology and clinical chemistry values for charles. Materials and methods animals male wistar rats 45 weeks old and with a body weight 150180 g were obtained from the slac laboratory animal, shanghai, china. Artesunateamodiaquine asaq is an antimalarial drug. Pritchett and others published biology and medicine of. Original article antiinflammatory effect of emodin on lipopolysaccharideinduced keratitis in wistar rats guoling chen 1, jingjing zhang2, han zhang, ying xiao 1, xin kao, yanli liu3, zhiyu liu3 1department of ophthalmology, the second hospital of shandong university, jinan, china.
Are there differences between spraguedawley and wistar rats in. The study investigated the effect of calabash chalk on the uterus of adult female wistar rats. Windows often associates a default program to each file extension, so that when you doubleclick the file, the program launches automatically. India abstract the aim of the present context to evaluated to the immunomodulatory activity of hydroalcoholic extract of. K mohanty1 and s b kasture2 1, vns institute of pharmacy, bhopal, m. Biochemical and histopathological studies on female and. Vitamin d content of the complex was assessed by hplc. The effects of lglutamine on castor oil induced diarrhea.
Ovariectomized spraguedawley sd and wistar rats are widely used as animal models for postmeno pausal osteoporosis. Ameliorative effects of melatonin 1idris sherifat banke, 2ambali suleiman folorunsho, 3onukak charles, 3mohammed m. File extensions tell you what type of file it is, and tell windows what programs can open it. All domain and bridge xml files are templated and associated with an image type.
Located in the university city section of philadelphia, wistar was founded in 1892 as americas first nonprofit institution solely focused on biomedical research and training. Humoral and cellular immune response in wistar han rcc. This particular colony was selected because of a low incidence of hydronephrosis. The wistar institute is an independent, nonprofit research institution in biomedical science, with special expertise in oncology, immunology, infectious disease and vaccine research. Are there differences between spraguedawley and wistar. Health status of male adult wistar rats from two experimental. A parametric analysis of the growing cfhb wistar rat. Wistar albino rats were exposed to 30 or 100 ppm fluoride as naf in drinking water during their fetal, weanling, and postweaning stages. India 2, pinnacle biomedical research institute, bhopal, m. Fourteen male wistar rats were divided into 2 groups. The study was conducted on 40 female wistar rats which were given the full or half dose of immunosuppressants in combinations commonly used in the treatment of kidney transplant recipients. Aframomum melegueta of the family zingiberaceae is a spice used in west africa for the purpose of alleviating stomachache, diarrhea and hypertension. Bg was lowered to 150mgdl after which a constant 50ulmin jugular iv infusion of saline n7 or 4mgml of gaba n9 started t10 min.
We would like to show you a description here but the site wont allow us. In this study, the antidiarrheal effect of aqueous extracts dried and fresh forms of m. Subchronic chlorpyrifos and cypermethrininduced sensorimotor changes in male wistar rats. The aim of this study was to evaluate the effects of a diet containing gm soybean meal rur on male and female wistar rats. Toxicologycarcinogenicity national toxicology program. Fluoride content in soft tissues and urine of rats exposed. Therefore we studied whether wistar rats obtained from harlan laboratories ha, n 24 and charles river cr, n 22 had a different outcome in an acute myocardial infarction ami model.
A strain of albino rat developed at the wistar institute that has spread widely at other institutions. Calcium chloride and vitamin d fortified beverages. Forty male wistar albino rats were divided into four groups. Hematobiochemical changes of lead poisoning and amelioration with ocimum sanctum in wistar albino rats sujatha k.
This study aimed to investigate differences in the longterm effects of ovariectomy on these two breeds of rats. Comparison between spraguedawley and wistar rats as an experimental model of pharmacokinetic alterations induced by spinal cord injury. What is the difference between wistar albino rats, sprague dawley and long evans rats. Eightweek old male wistar rats weighing about 180 g were given sodium fluoride in drinking water at a concentration of 5 and 25 mg fl for 12 weeks. To evaluate the protective effect of tamarind pulp against fluoride finduced oxidative stress in the liver, adult fe male wistar rats were treated daily for 45 days with sodium fluoride 300 ppm naf 6. Wistar rats with a powder diet containing 60% bt rice for 90 days did not induce the anticry1ab igg and ige antibody production in the animals, feeding wistar rats with the powder diet containing 60% bt rice spiked with 0. Origin and development the wild brown rat rattus norvegicus is thought to have had its original habitat in the temperate areas of what is now the ussr, from the caspian sea to northern china.
The effect of calabash chalk on the uterus of adult female. The wistar rat, wistar hannover wistar han rat, and wistar unilever wu rat are outbred rat strains, while the wistar kyoto and wistar furth rats are inbred strains. To document the reproducibility between experiments, the age of vaginal opening is reported for all. Acute toxicity studies were carried out on wistar rats by the oral route at dose levels up to 2000 mgkg of the tuber extract of ipomoea batatas as per the oecd guidelines no. Wistar rats long ears, tail length shorter than body length and wider head. This study was carried out to investigate the effect of lead exposure on kidney function. The aim of this study is to evaluate the effects of aframomum melegueta on the liver of adult wistar rats. It was teratogenic and fetotoxic in wistar rats when given orally or topically in doses greater than 1 mgkgday. Antiinflammatory activity of hydroalcoholic extract of. Original article the chronic effects of 5aminolevulinic. Wistar outbred rats show close genetic similarity with. The body weights, food consumption, hematology, serum biochemistry, organ weight, and histopathological examination were compared between rats fed on gm soybean and those.
Group a served as the control while groups b and c served as experimental groups. Roof rats may have black, gray, or brown fur, and a long. However, variations in teratogenic doses among various strains of rats have been reported. Sexspecific reference intervals of hematologic and. Scge to detect dna damage in brain cells of adult rats exposed to high fluoride and low iodine for an extended period of time. Male wistar rats and c57bl6 mice were tested in a oneday water maze task in which spatial learning, retention, and nonspatial learning were assessed within 3h. Winkelmann, borchen employed in 9 control groups from 7 different 30month studies were compiled on the basis of histopathology reports. Age related changes in nad metabolism oxidative stress. The zucker fatty rat as a genetic model of obesity and hypertension pdf.
Pdf in summary, the creation and maintenance of the wistar rats as standardized animals can be attributed to the breeding work of helen. Their body weights were measured on a weekly basis throughout the experimental period. Comparison between spraguedawley and wistar rats as an. Original article antiinflammatory effect of emodin on.
Guillemin1,2, hussein mansour3, tailoi chanling3, anne poljak4, ross grant1,5 1department of pharmacology, school of medical sciences, faculty of medicine, university of new south wales, sydney, australia, 2st vincents centre for applied. Get a printable copy pdf file of the complete article 1. Efforts aimed at ameliorating this condition is very imminent. Pubertal development in female wistar rats following exposure to. After two and four weeks of treatment, five animals from each group were killed. As in our recent reports,1214 onemonth old wistar albino rats, each weighing approximately 50 g, were obtained from the. Roundup ready became the most cultivated genetically modified gm crop in the world. Cannabidiol disrupts the reconsolidation of contextual. The aim of the present context to evaluated to the antiinflammatory activity of hydroalcoholic extract of quisqualis indica in wistar rats.
Fluoride content in soft tissues and urine of rats exposed to sodium fluoride in drinking water i inkielewicz,a j krechniaka,b gdansk, poland summary. Wistar automates all of this behind some useful abstractions. The wistar institute is a global leader in biomedical research with special expertise in cancer, immunology, infectious diseases and vaccine development. Rearrange individual pages or entire files in the desired order. Neonicotinoid study index 2017 mammalian toxicity studies author year title link aboudonia et al. Pdf toxic effect of lead on kidney function in rat wistar.
Like human beings, the wistar rats go through the ontogenetic developmental stages prenatal. Twenty wistar rats weighing between 180215kg were used. They have relatively slender bodies compared to norway rats, and larger ears and eyes. Wihan rats and b6c3f1n mice gavage studies 2014 longterm carcinogenicity tr586. Intoxicated rats ym shivaraiashankara, ar shivashankara, p gopalakrishna bhat,b s muddanna rao. Social interaction and conditional selfdiscrimination. Oral tretinoin has been shown to be teratogenic in rats, mice, hamsters, and subhuman primates.
The result is that we can quickly spin up and experiment on topologies of vms. The rats were fasted for 12 hours prior to the commencement of the experiment. Oxidative stress, cholinesterase activity, and dna damage. The 15 female adult wistar rats were randomly divided into groups a, b and c. Toxicology studies of tetrabromobisphenol a casrn 79947 in f344ntac rats and b6c3f1n mice and toxicology and carcinogenesis studies of tetrabromobisphenol a in wistar han crl. Wistar outbred rats show close genetic similarity with f344 inbred rats satoshi nakanishi1, tadao serikawa1, 2, and takashi kuramoto1 1institute of laboratory animals, graduate school of medicine, kyoto university, yoshidakonoecho, sakyoku. A file extension is the set of three or four characters at the end of a filename. Female wistar rats were housed under incandescent lighting and randomly divided into the treatment and control groups. The wistar bloodline has contributed more strains of rats than any other line. Group 1 was the control, while groups 2, 3 and 4 were each orally administered with a type of the energy drinks daily for 4 weeks. Differences in types and incidence of neoplasms in wistar han and. Flavored beverages were formulated with various ratios of calcium and vitamin d in a 4x4 factorial design. A laboratory rat or lab rat is a rat of the species rattus norvegicus domestica which is bred and. In this study, we establish sexspecific reference intervals of hematologic and biochemical analytes in control group spraguedawley rats by using internationally accepted clsi and asvcp guidelines.
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